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Description

10.1002/gps.1469 Int

227 NLRP3 promotes PAEC ferroptosis in PAH Ferroptosis, an apoptotic-independent mode of cell demise activated through iron-dependent lipid peroxidation, plays a pivotal role in the development of various inflammation-associated diseases

The default location is at the plasma membrane of the cell, and lipid peroxidation is unlikely to occur at other subcellular sites: mitochondria, endoplasmic reticulum, and lysosomes